Osteoarthritis is the most prevalent form of arthritis, with an associated risk of mobility disability (defined as needing help with walking or climbing stairs) for those with affected knees being greater than that due to any other medical condition in people aged ≥ 65. Osteoarthritis of the knee causes pain, limits activity, and impairs quality of life. The societal burden (both in terms of personal suffering and use of health resources) is expected to increase with the increasing prevalence of obesity and the ageing of the community.
Osteoarthritis is a multifactorial process in which mechanical factors have a central role and is characterized by changes in structure and function of the whole joint. There is no cure, and current therapeutic strategies are primarily aimed at reducing pain and improving joint function.