Osteoarthritis
Osteoarthritis (OA) is the most common condition to affect synovial joints and causes significant dysfunction and disability. Because osteoarthritis increases significantly with age, it was long considered to be a degenerative disease that was an inevitable consequence of ageing and trauma. However, it is viewed now as a metabolically dynamic process characterized by an imbalance of joint breakdown in association with a maladaptive and insufficient repair process.