Knee n-STRIDE APS Injection for Osteoarthritis
Knee osteoarthritis (OA) is a common degenerative disease characterized by chronic pain, joint stiffness, reduced function, cartilage degradation, loss of subchondral bone, and synovial inﬂammation. Although symptoms may be alleviated with conservative therapies such as analgesic drugs, lifestyle modiﬁcations, and physical therapy, no disease-modifying treatment is currently available. In the end phase of OA, joint replacement surgery is currently considered the only solution to relieve symptoms.
New approaches that harness our understanding of early OA may allow for earlier intervention than joint replacement. One mechanism of knee OA progression is a degenerative feed-forward cycle caused by pathological increases in inﬂammatory cytokines and catabolic factors within and adjacent to the synovial space. Inﬂammatory and catabolic proteins such as interleukin-1 beta (IL-1b), tumor necrosis factor alpha (TNFa), and matrix metalloproteinases ( MMPs), for example, have been implicated in cartilage degradation and continued OA progression.
Approaches to block these deleterious proteins could improve patients’ symptoms, and perhaps the progression of the disease may be halted or even reversed. Autologous blood contains a host of proteins, which can block the action or production of inﬂammatory and catabolic proteins. A strategy to overcome the pathologically high levels of proinﬂammatory and catabolic proteins, which contribute to OA, would be to introduce highly concentrated amounts of anti-inﬂammatory and anabolic proteins into the environment.
Indications for n-STRIDE APS treatment
Treatment options for Knee Osteoarthritis
Treatment depends on the severity of the osteoarthritis. Conservative treatments include analgesics and corticosteroid injections to relieve pain and inflammation, and physiotherapy and prescribed exercise to improve function and mobility. When symptoms are severe, surgery may be indicated: options include upper tibial osteotomy and unicompartmental or total knee replacement.