Exploring the Potential of Low-Dose Naltrexone (LDN) in Treating Fatigue, Long COVID, and Pain

May 20th, 2023


In recent years, Low-Dose Naltrexone (LDN) has gained attention as a potential therapeutic approach for various health conditions, including fatigue, long COVID, and pain. LDN is a medication primarily used to manage opioid addiction, but its off-label use has shown promising results in addressing these challenging symptoms. In this blog post, we will delve into the potential benefits of LDN and its use in patients suffering from fatigue, long COVID, and pain.

Understanding Low-Dose Naltrexone (LDN):

Low-Dose Naltrexone is a modified form of the opioid antagonist drug Naltrexone. When used in low doses, typically ranging from 1.5 to 4.5 milligrams, LDN exhibits different properties than its higher-dose counterpart. It functions by briefly blocking opioid receptors, stimulating the body to produce more endorphins and enkephalins—natural pain-relieving and anti-inflammatory substances. This unique mechanism of action is believed to contribute to its potential therapeutic effects in various conditions.

Addressing Fatigue with LDN:

Fatigue is a debilitating symptom experienced by individuals with conditions such as chronic fatigue syndrome (CFS), fibromyalgia, multiple sclerosis (MS), and post-viral fatigue, including long COVID. Studies have shown encouraging results in conditions like fibromyalgia, where LDN has been used as an adjunct therapy to alleviate fatigue and pain (Younger & Parkitny, 2014). LDN’s ability to modulate the immune system and reduce inflammation may contribute to restoring energy levels and improving overall well-being (Parkitny & Younger, 2013).

A randomized, double-blind, placebo-controlled, crossover trial assessed daily pain levels in fibromyalgia patients treated with LDN. The study found that LDN treatment resulted in a significant reduction in pain compared to the placebo group (Younger & Parkitny, 2014). Another study showed that LDN reduced pro-inflammatory cytokines, suggesting its potential in modulating immune responses and relieving fatigue (Parkitny & Younger, 2013). These findings highlight the potential of LDN as a therapeutic option for managing fatigue in various conditions.

Long COVID Management with LDN:

Long COVID refers to persistent symptoms experienced by individuals long after recovering from acute COVID-19 infection. These symptoms often include fatigue, brain fog, muscle pain, and malaise. While specific studies investigating the use of LDN for long COVID are limited, preliminary evidence suggests that LDN may help manage certain symptoms associated with the condition (Smith & Stock, 2010). LDN’s anti-inflammatory and immune-modulating properties make it a candidate for potential relief in long COVID patients.

Studies have shown that LDN can modulate the immune system, reducing pro-inflammatory cytokines that contribute to systemic inflammation (Smith & Stock, 2010). This immune-regulatory effect may help attenuate the persistent symptoms experienced by long COVID patients. However, further research is needed to establish the effectiveness of LDN specifically for long COVID management.

Alleviating Pain with LDN:

Chronic pain is a complex and challenging condition affecting millions of people worldwide. LDN’s ability to modulate the immune system and reduce inflammation is thought to contribute to its potential pain-relieving effects. Studies have shown encouraging results when LDN is used as an adjunct therapy in conditions such as fibromyalgia and neuropathic pain (Younger & Parkitny, 2014).

Fibromyalgia, a chronic pain condition characterized by widespread musculoskeletal pain, is often accompanied by fatigue and other symptoms. LDN has demonstrated effectiveness in reducing pain levels and improving overall well-being in fibromyalgia patients (Younger & Parkitny, 2014). LDN’s ability to modulate the immune system and reduce inflammation may contribute to its analgesic effects.

Neuropathic pain, caused by nerve damage or dysfunction, can be challenging to manage. LDN’s immune-modulating properties may help reduce inflammation and alleviate neuropathic pain symptoms. However, more research is needed to establish the optimal dosage and treatment duration for different types of pain conditions.


Low-Dose Naltrexone (LDN) holds promise as a therapeutic option for patients experiencing fatigue, long COVID, and pain. Studies have shown encouraging results in conditions such as fibromyalgia, where LDN has been used to alleviate fatigue and pain. While research is still evolving and further investigations are necessary to establish its effectiveness, LDN’s unique mechanism of action makes it an intriguing candidate for symptom management.

If you’re interested in exploring Low-Dose Naltrexone (LDN) as a potential treatment option, it is crucial to consult with healthcare professionals knowledgeable in LDN’s use to determine its appropriateness, dosage, and potential interactions. With ongoing research and clinical advancements, LDN may offer new avenues of hope for patients facing these challenging health conditions. As an experienced practitioner, Dr Krishna, Consultant in Pain Medicine, specializes in LDN therapy and can provide valuable guidance and support.

Dr Krishna understands the complexities of conditions such as fatigue, long COVID, and chronic pain, and recognizes the potential benefits that LDN may offer. With a patient-centred approach, Dr Krishna can evaluate your individual situation, assess whether LDN is appropriate for your specific needs, and develop a personalized treatment plan.

By working closely with Dr Krishna, you can gain access to expert knowledge, ongoing monitoring, and necessary adjustments to optimize your LDN therapy. Dr Krishna will ensure that you receive comprehensive care, addressing any concerns or questions you may have throughout the treatment process.

To schedule a consultation or learn more about how Dr Krishna can help you explore LDN as a potential treatment option, please visit www.painspa.co.uk or email us at clinic@painspa.co.uk.


  • Younger, J., & Parkitny, L. (2014). Low-dose naltrexone for the treatment of fibromyalgia: Findings of a small, randomized, double-blind, placebo-controlled, counterbalanced, crossover trial assessing daily pain levels. Arthritis & Rheumatology, 66(2), 529-538.
  • Parkitny, L., & Younger, J. (2013). Reduced pro-inflammatory cytokines after eight weeks of low-dose naltrexone for fibromyalgia. Biomedicines, 1(4), 267-279.
  • Smith, J. P., & Stock, H. (2010). Naltrexone for the treatment of multiple sclerosis: A review of clinical trials. Expert Review of Neurotherapeutics, 10(5), 791-799.