Arthrosamid for Knee Osteoarthritis

Knee osteoarthritis (OA) is a long-term condition where shock-absorbing cartilage is worn away causing bones to rub together and the joint to become stiff, swollen and painful. The knee joint worsens over time resulting in synovial pain and disability. Arthrosamid® is a single, minimally invasive, long-lasting knee osteoarthritis (OA) treatment — a non-biodegradable injectable polyacrylamide hydrogel (2.5 iPAAG) for intra-articular use. PAAG hydrogel (Arthrosamid) represents a good treatment option for those suffering with knee OA. All studies included show a reduction in mean WOMAC pain, stiffness, physical function score over all periods of time at follow up and show numerical superiority to current options such as hyaluronic acid in a randomised control trial. PAAG hydrogels have also been shown to be safe and have no long-term effect when injected into the knee.

icon

Arthrosamid for Knee Osteoarthritis Summary

Knee osteoarthritis (OA) is a long-term condition where shock-absorbing cartilage is worn away causing bones to rub together and the joint to become stiff, swollen and painful. The knee joint worsens over time resulting in synovial pain and disability.

No therapies have been able to satisfactorily halt or delay OA progression or provide effective, long-lasting symptomatic relief.

When these therapies fail, joint replacement surgery (with an artificial prosthesis) is often the only option to improve pain sensation and patient quality of life. With joint replacement surgery having previously been the only option for those with late-stage knee osteoarthritis, Arthrosamid® is redefining treatment for patients living with knee pain.

Researched for more than two decades, Arthrosamid® has been proven to maintain a statistically significant reduction in pain in patients with knee OA 3 years after treatment.

Single injections of 6 ml intra-articular Arthrosamid ® are well tolerated and continue demonstrate clinically relevant and statistically significant effectiveness 3 years after treatment.

Indications For Arthrosamid

  • Chronic knee pain secondary to osteoarthritis
  • Poor response to conservative management
  • Unfit for knee replacement
  • Want to avoid surgerY

Knee Osteoarthritis (oa) And Treatment Options

Knee osteoarthritis (OA) is a long-term condition where shock-absorbing cartilage is worn away causing bones to rub together and the joint to become stiff, swollen and painful. The knee joint worsens over time resulting in synovial pain and disability.

No therapies have been able to satisfactorily halt or delay OA progression or provide effective, long-lasting symptomatic relief.

Treatments to date have focused on pain relief and managing the symptoms of the condition — meaning that the options available to the one-third of over 65s currently living with osteoarthritis (OA) worldwide have been limited to:

  • Exercise
  • Weight loss
  • Pain relief medication
  • Viscousupplement (hyaluronic acid) Injections
  • Braces
  • Physio

When these therapies fail, joint replacement surgery (with an artificial prosthesis) is often the only option to improve pain sensation and patient quality of life. With joint replacement surgery having previously been the only option for those with late-stage knee osteoarthritis, Arthrosamid® is redefining treatment for patients living with knee pain.

What Is Arthrosamid®?

Based on an innovative non-biodegradable hydrogel technology, Arthrosamid® is 2.5% cross-linked polyacrylamide and 97.5% water.

The medical description of Arthrosamid® is an ‘injectable polyacrylamide hydrogel’ otherwise known as ‘2.5 iPAAG’.

Approved for treatment of knee OA, Arthrosamid® is suitable, safe and effective for most patients with the condition.

Arthrosamid® is the first and only approved injectable treatment that permanently combines with the knee’s synovial tissue15 — decreasing joint stiffness, diminishing pain, improving the function of the knee, and enhancing your quality of life.

Arthrosamid®: Mechanism Of Action

Arthrosamid® is a first-in-class synovial scaffold delivered as a single, minimally invasive out-patient procedure performed under local anaesthesia, with ultrasound guidance.

Arthrosamid® combines with the tissue lining your knee joint, thickening it to provide a barrier — reducing your pain.

Arthrosamid® permanently combines with the tissue lining your knee joint and it is this unique characteristic that provides a significant reduction in your OA pain over a longer periods — with one single treatment

Why Choose Arthrosamid®?

No therapies have been able to satisfactorily halt or delay OA progression or provide effective, long-lasting symptomatic relief for patients with knee OA. So, until now, treatments have tended to focus on pain relief and the management of symptoms through:

  •  Weight loss
  • Exercise and physiotherapy
  • Walking aids
  • Footwear and insoles
  • Knee braces
  •  Oral pain relief medication
  • Viscosupplement Hyaluronic Acid (HA) injections

and when these therapies fail

  •  Joint replacement/ knee surgery

Arthrosamid® is the first and only approved 2.5 iPAAG treatment that permanently integrates into the synovial membrane — decreasing joint stiffness, diminishing pain, and improving the function of the knee. It provides a relaible option for patients who do not want to undergo surgery or are unfit to have surgical treatments.

Benefits Of Arthrosamid

Unlike hyaluronic acid injectables — where there is very little evidence to show that the effect is still noticeable at six months Arthrosamid® provides a significant reduction in your knee OA pain over a longer period with one single treatment.

Treatment with Arthrosamid® is a simple, one-step outpatient procedure  performed in a day that doesn’t involve the disruptive recovery period usually associated with surgery.

Pain reduction

In all the studies Arthrosamid® exceeds the MCID of 9 points 16 and improvement is maintained up to 3 years after a single injection.

Close to 80% Response rate

Patients in the under 70 years group reported close to 80% positive response rate following treatment with Arthrosamid®.

A single, minimally invasive, long-lasting  knee OA treatment, Arthrosamid® has demonstrated an improvement in quality of life with patients in clinical trials reporting a reduction in pain by Week 4 — and lasting over 3 years.

Evidence

Researched for more than two decades, Arthrosamid® has been proven to maintain a statistically significant reduction in pain in patients with knee OA 3 years after treatment.

Single injections of 6 ml intra-articular Arthrosamid ® are well tolerated and continue demonstrate clinically relevant and statistically significant effectiveness 3 years after treatment.

Bliddal, H., et al. (2023) A Prospective Study of Polyacrylamide Hydrogel Injection for Knee Osteoarthritis: Results From 3 Years After Treatment. Osteoarthritis and Cartilage. Vol 31(5): 682-683.

Safety Profile & Effectiveness

Arthrosamid® remains safe and effective for its intended use 3 years after treatment.

Safety of intra-articular polyacrylamide hydrogel (iPAAG) for the treatment of knee osteoarthritis symptoms

16% of the participants had received arthroplasty surgery for knee OA of the treated knee.

There were no unexpected descriptions of abnormalities that could be associated with the prior treatment with iPAAG in the surgical reports.

(Overgaard, A., et al. (2019). Safety of intra-articular polyacrylamide hydrogel for the treatment of knee osteoarthritis symptoms: A retrospective case series. Clin Ortho Adv Res. Osteoarthritis and Cartilage. Vol 30(1): S370-71. DOI:10.1016/j.joca.2022.02.497.)

“Of these patients, none reported dissatisfaction with the outcome of the surgery and the arthroplasties were well functioning.”

Contraindications

Arthrosamid® should not be injected:

  • If an active skin disease or infection is present at or near the injection site.
  • If the joint is infected or severely inflamed.
  • If the patient has previously received treatment with a different non-absorbable injectable/implant.
  • If the patient has received a knee alloplasty or has any foreign material in the knee.
  •  If the patient has undergone knee arthroscopy within the last six months.
  •  In haemophilia patients or in patients in uncontrolled anti-coagulant treatment.

Arthrosamid Rehabilitation Programme

While knee osteoarthritis cannot be cured, we believe a long-term commitment to exercise can significantly improve your patients’ chances of leading a more active life with reduced knee pain.

Please click on the link below to take advantage of a comprehensive rehabilitation programme guided by 2 highly experienced physiotherapists.

https://arthrosamid.com/rehab

Have a question about Arthrosamid for Knee Osteoarthritis?
Or would like to book in with us?

0117 2872383

Get In Touch
murli

Dr Murli Krishna

Consultant Pain Medicine